Breast Cancer Panel
Understanding metastatic breast cancer one cell at a time.
Figure 1. Composites of breast cancer panel.
Epic’s new mBCa panel targets therapeutic markers across the majority of current clinical trials. By looking at CTCs with single cell resolution, we gain insight into a patients hormonal status (ER,PR,HER2,AR), tumor heterogeneity and HRD status (CTC phenotype), in the active metastatic portion of the disease...CTCs. Using these tools we can better understand therapeutic response vs. both standard of care and clinical trial drugs throughout the course of treatment. Further, the application of single cell genomic profiling (targeted resequencing, whole genome CNV and tumor mutational burden) to these cells provides simultaneous genotypic and phenotypic insights.
Figure 2. CTCs from a single metastatic breast cancer patient at a single time point.
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Every time Epic’s AR-V7 test is administered the healthcare system saves about $15,000 per year of life extended. In other words approximately $7,000 to $9,000 per patient tested.
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Of the roughly 30 million cells in a typical blood sample, about 5 are cancer cells on their way to form tumors elsewhere in the body. Modern cancer diagnostics technology can't see them.
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We spend about $100 billion a year on cancer drugs. But because we’re not matching the right drug to the right patient and their disease in a personalized way, about 3/4ths of that drug spend is wasted.
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The Epic approach answers a critical question for a doctor: When is a patient resistant? By answering that question accurately and precisely we increase patient life and save the system money at the same time.
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Today, Epic Sciences is embedded in clinical trials with 48 leading producers of oncology drugs and 35 of the top academic cancer hospitals.
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It takes only 7 minutes to acquire an entire image of 6 million stained cells on a 1 x 3 slide. Then that image, which is about 20GB of data, gets sent up to the cloud where the algorithms run and find the rare events in about 2 more minutes.