Metastatic cancer is a cagey adversary, a shape- and form-changing disease that can be understood only by following its dynamics at a cellular level. Most tests are based upon fixed assumptions of what cancer looks like, however, they come up short. For that reason, Epic Sciences chose a research road less traveled, a bias-free approach that looks at all the cells in a non-invasive blood sample, and thus sees those rare cells that others miss.
Every cancer is as unique as the person who carries it. So the tests that diagnose and monitor the illness must be eminently personal, proven and precise.
If you can’t see the problem, you can’t solve it.
Maximizing a revolutionary component: Certainty.
Epic’s new AR-V7 CTC liquid biopsy test is the first clinically proven predictive test for metastatic castration-resistant prostate cancer. This test requires but a simple blood draw and is unambiguous, giving doctors a clearer picture of a patient's metastatic disease, thus allowing them to proceed with confidence and certainty while sparing patients the anxiety associated with the uncertainty of an uninformed choice.
A bias-free vision of cancer research.
At Epic Sciences, we develop clinical solutions that accelerate drug development and provide valuable insights into the dynamics of cancer growth, evolution and heterogeneity. Our AR-V7 CTC test, for example, has demonstrated predictive clinical utility for prostate cancer. It’s but one example of our dedication to the development of proven tests to guide therapy selection across the most impactful drug classes in oncology.
ASCO GU 2019: A Phase II Trial in Progress: Pamiparib, an Investigational PARP Inhibitor, in Patients with mCRPC and a Circulating Tumor Cell Homologous Recombination Deficiency Phenotype or BRCA Defects
San Francisco, CA (UroToday.com) Prostate cancer is one of the leading causes of cancer deaths in men. Patients with metastatic castration-resistant prostate cancer (mCRPC) who have a BRCA1/2 mutation or mutations in other homologous recombination deficiency genes have aggressive disease and a worse prognosis. Poly (ADP-ribose) polymerase (PARP) proteins are a family of proteins involved in DNA repair, genome stability, and programmed cell death. Inhibition of PARP proteins allows for the accumulation of unrepaired single-strand breaks, which are converted to double-strand breaks during cell division and can lead to apoptosis/cell death. DNA repair can be compromised by the absence of homologous recombination components such as BRCA1 or BRCA2.
Circulating Tumor Cell Capture Technologies Expand in 2018
NEW YORK (GenomeWeb) – The market for circulating tumor cell (CTC) capture and detection grew significantly in 2018 as several companies pushed toward clinical implementation of their technologies for diagnosing multiple cancers, while new firms spun out of academic institutions with their own technologies. In order to diagnose cancer clinicians have traditionally performed tissue biopsies, which can be invasive, expensive, and time-consuming for patients. Over the last decade, however, liquid biopsy tools have emerged as a way to address these issues and perhaps provide a more accurate picture of individual patients' disease.
The Race to Diagnose Cancer With a Simple Blood Test
Five years ago, a team of researchers pored over the results of a prenatal genetic test given to more than 125,000 healthy pregnant women and made a stunning discovery. The blood test, marketed by gene-sequencing giant Illumina, was designed to detect chromosome anomalies associated with conditions such as Down syndrome by analyzing fragments of fetal DNA circulating in the mother’s blood. In 3,757 of the tests, the scientists found at least one abnormality. But in 10 of those cases, further analysis revealed that the fetuses were in fact normal. “In every one of those 10 cases, it turned out there was an undiagnosed cancer” in the mother, says Alex Aravanis, who at the time of the study was the senior director of research and development at Illumina.
New Study Reports Blood Test Can Predict Optimal Treatment for Advanced Prostate Cancer
San Diego, Coherent Chronicle — Researchers from Lawson Health Research Institute suggested that a blood test can help predict efficiency of a treatment in advanced prostate cancer. The Lawson Health Research Institute in collaboration with the Memorial Sloan Kettering Cancer Center and the Royal Marsden and Epic Sciences, demonstrated that a blood test can predict the responses of patients suffering from advanced prostate cancer to specific treatments.