Virtually all men with metastatic prostate cancer will eventually develop mCRPC, an advanced stage of the disease. To spare patients and physicians the anxiety around choosing a correct therapy we’d like to suggest a novel test, requiring only a simple blood draw, that will allow them to proceed with confidence: Epic Sciences’ AR-V7 CTC liquid biopsy test — a test so sensitive and so precise that doctors can predict with confidence which therapies will be beneficial and which will not.
The world’s first predictive test for prostate cancer.
Our AR-V7 test for prostate cancer was the result of a radically different approach to cancer research. Rather than developing a technology and trying to find out where it might be useful in the field, we started with the clinical question. This has allowed us to tailor our technology — whether it’s higher resolution images, different stains and antibodies, or different morphological features — to answer that clinical question, and in turn drive our development program. It’s a bias-free approach — a unique rare cell detection engine that looks at all the cells in a blood sample and sees the cancer cells that others miss.
Epic’s technology can thus see, identify and characterize all the circulating tumor cells (CTCs) in a blood sample, and link their response or resistance to a panoply of drug classes. Specifically, the Epic AR-V7 test identifies patients who are likely to be resistant to androgen-directed therapies such as Zytiga® or Xtandi®. Thus alerted, a physician might instead choose to triage the patient with a taxane chemotherapy, which has been statistically shown to increase a patient’s overall chances of survival (JAMA Oncology, 2016).
Few things are certain in life, but the knowledge that you’ve made an informed choice and perhaps helped someone live a longer, healthier life is welcome news at any time.
Figure 1. KM Curve of pre-therapy AR-V7 status: AR-V7 positive patients show resistance to AR Signaling Inhibitors and thus exhibit shorter overall survival.